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rs1190999960
|
|
|
0.020 |
GeneticVariation |
BEFREE |
When the role of SCF<sup>Skp2/Cks1</sup>-mediated p27 ubiquitination in cancer was specifically tested by p27 Thr187-to-Ala knockin (p27T187A KI), it was found dispensable for Kras<sup>G12D</sup>-induced lung tumorigenesis but essential for Rb1-deficient pituitary tumorigenesis.
|
27181203 |
2017 |
|
rs1190999960
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age.
|
25583987 |
2015 |
|
rs132770
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Sensitivity analyses were also performed.The rs2267437 polymorphism was associated with a significant increase in risks of overall cancers, breast cancer, renal cell carcinoma and hepatocellular carcinoma, and it could increase the cancer risk in Asian population; the rs5751129 polymorphism could increase the cancer risk in overall cancers; the rs132770 polymorphism was associated with the increased renal cell carcinoma risk; furthermore, the rs132793 polymorphism could decrease breast cancer risk and increase risks in "other cancers".Overall, the results provided evidences that the single nucleotide polymorphisms in XRCC6 promoter region might play different roles in various cancers, indicating different cancers have different tumorigenesis mechanisms.
|
25569644 |
2015 |
|
rs2267437
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Sensitivity analyses were also performed.The rs2267437 polymorphism was associated with a significant increase in risks of overall cancers, breast cancer, renal cell carcinoma and hepatocellular carcinoma, and it could increase the cancer risk in Asian population; the rs5751129 polymorphism could increase the cancer risk in overall cancers; the rs132770 polymorphism was associated with the increased renal cell carcinoma risk; furthermore, the rs132793 polymorphism could decrease breast cancer risk and increase risks in "other cancers".Overall, the results provided evidences that the single nucleotide polymorphisms in XRCC6 promoter region might play different roles in various cancers, indicating different cancers have different tumorigenesis mechanisms.
|
25569644 |
2015 |
|
rs5751129
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Sensitivity analyses were also performed.The rs2267437 polymorphism was associated with a significant increase in risks of overall cancers, breast cancer, renal cell carcinoma and hepatocellular carcinoma, and it could increase the cancer risk in Asian population; the rs5751129 polymorphism could increase the cancer risk in overall cancers; the rs132770 polymorphism was associated with the increased renal cell carcinoma risk; furthermore, the rs132793 polymorphism could decrease breast cancer risk and increase risks in "other cancers".Overall, the results provided evidences that the single nucleotide polymorphisms in XRCC6 promoter region might play different roles in various cancers, indicating different cancers have different tumorigenesis mechanisms.
|
25569644 |
2015 |
|
rs3218536
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Arg188His polymorphism might play different roles in carcinogenesis of various cancer types.
|
24621646 |
2014 |
|
rs1799782
|
|
|
0.030 |
GeneticVariation |
BEFREE |
However, we cannot exclude the possibility that the OGG1 Ser326Cys and XRCC1 Arg194Trp polymorphisms play minor roles in lung carcinogenesis.
|
15840879 |
2005 |
|
rs1799782
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The findings of the effect modification of the Arg(194)Trp on the relations of plasma alpha- and beta-carotene levels with breast cancer risk suggest a potential protective effect of carotenoids in breast carcinogenesis by preventing oxidative DNA damage.
|
14679022 |
2003 |
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rs1799782
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our data indicate that the Arg194Trp and Arg399Gln polymorphisms do not confer a significant risk for head and neck carcinogenesis.
|
15800678 |
2005 |
|
rs25487
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our data are consistent with a potential role of the XRCC1 Arg399Gln polymorphism in bladder cancer susceptibility and further suggest that there may be DNA lesions important in bladder carcinogenesis, repaired by the base excision repair mechanism, that are not directly associated with tobacco smoking.
|
15298955 |
2004 |
|
rs25487
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our data indicate that the Arg194Trp and Arg399Gln polymorphisms do not confer a significant risk for head and neck carcinogenesis.
|
15800678 |
2005 |
|
rs25487
|
|
|
0.030 |
GeneticVariation |
BEFREE |
XRCC1 Arg399Gln and GSTP1 Ile104Val polymorphisms may influence the CIHM status in the rectal mucosa of UC patients and may be substantially involved in UC-associated carcinogenesis.
|
21234761 |
2011 |
|
rs1057520009
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Emerging evidence suggests that the mutant XPO1 E571K plays a role in carcinogenesis, and this variant is quantifiable in tumor and plasma cell-free DNA of patients using highly sensitive molecular biology techniques, such as digital PCR and next-generation sequencing.
|
28196522 |
2017 |
|
rs2228001
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms in Lys939Gln XPC gene may diminish DNA repair capacity, eventually increasing the risk of carcinogenesis.
|
26604426 |
2015 |
|
rs12740674
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings confirmed the important role that genetic variants of noncoding sequence play in lung cancer susceptibility and indicated that rs12740674 in miR-1262 may be biologically relevant to lung carcinogenesis.
|
28510306 |
2017 |
|
rs1356083197
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To dissect the role of K-ras activation in bronchial epithelial cells during lung tumorigenesis, we created a model of lung adenocarcinoma by generating a conditional mutant mouse with both Clara cell secretory protein (CC10)-Cre recombinase and the Lox-Stop-Lox K-ras(G12D) alleles.
|
16288213 |
2006 |
|
rs5030821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
VHL-R167Q binds elongin C and elongin B with considerably less avidity than wild-type VHL does but retains residual capacity to generate a VHL-elongin C-elongin B complex, downregulate HIF2α, and suppress tumorigenesis</span>, which could be rescued by increase of VHL-R167Q levels.
|
24755468 |
2014 |
|
rs1372834410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also noted that the nonphosphorylatable mutant Vgll4-4A (S58A/S155A/T159A/S280A) suppressed tumorigenesis in pancreatic cancer cells <i>in vitro</i> and <i>in vivo</i> to a greater extent than did wild-type Vgll4, suggesting that mitotic phosphorylation inhibits Vgll4's tumor-suppressive activity.
|
28739871 |
2017 |
|
rs7664413
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that the two SNPs of VEGF-C (rs7664413 and rs2046463) and either of two haplotypes of five SNPs combined have potential predictive significance in oral carcinogenesis.
|
23593187 |
2013 |
|
rs1989969
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study demonstrated that VDR rs1989969 polymorphism was involved in the carcinogenesis of gastric cardiac adenocarcinoma, especially increased the risk in the younger and alcohol drinking Chinese population.
|
28489590 |
2017 |
|
rs80291436
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, we found that the L104P mutation in the VCX gene (Variable charge, X-linked) was absent in white blood cell samples, but present at 11.1% frequency in the adjacent tissues and increased to 14.6% in HCC tissues, suggesting that this mutation might be a tumor driver gene driving HCC carcinogenesis.
|
28412734 |
2017 |
|
rs228648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, these results strongly suggest that urotensin-II could contribute to breast carcinogenesis and Thr21Met polymorphism can be an important risk factor in developing breast tumors.
|
25604143 |
2015 |
|
rs246079
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data clearly suggest an association between UNG rs246079 (A/G) and CSCC carcinogenesis, supporting the potential application of this polymorphism as a genetic biomarker for early prediction of cervical carcinoma.
|
30572497 |
2018 |
|
rs1453340173
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We substituted Val285 with Ala (V285A) in an Ala-Val dipeptide, to mimic the conserved Ala-Ala in many members of the basic leucine-zipper family of transcription factors, important in gene regulation, cell proliferation and oncogenesis.
|
30566668 |
2019 |
|
rs35592567
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Together, these results suggest that rs35592567 in TP63 may be a novel causal variant contributing to the susceptibility to bladder cancer, which provides additional insight into the pathogenesis of bladder carcinogenesis.
|
26695686 |
2016 |